Potassium channel blockers differentially affect carbachol and (−)-N6-phenylisopropyladenosine on guinea-pig atria
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چکیده
منابع مشابه
Inhibitory effects of potassium channel blockers on carbachol-induced contraction in rat detrusor muscle.
We present accidental findings that potassium channel blockers, such as tetraethyl-ammonium (TEA) or 4-aminopyridine (4-AP), inhibit the sustained tonic contraction induced by carbachol in rat detrusor muscle strips. The relatively lower concentrations (<2 mM) of TEA and 4-AP inhibited phasic and tonic contractions induced by 5 micro M carbachol, whilst the relatively higher concentrations of T...
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In isolated 32P-labeled guinea pig ventricular cardiomyocytes phospholamban (PLB), myosin light chain 2 and the inhibitory subunit of troponin (Tnl) were identified by antibodies. In isolated 32P-labeled guinea pig ventricular cardiomyocytes isoproterenol (0.1 mumol/l) increased phosphorylation of PLB and of the inhibitory subunit of Tnl to 159 and 119% of control, respectively, without effect ...
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Intracellular potassium activity in guinea pig left atria was measured using potassium ion-selective microelectrodes and conventional microelectrodes. The effects of extracellular potassium concentration and acetylcholine on both intracellular potassium activity and the relationship between the resting membrane potential and the potassium equilibrium potential were investigated. Intracellular p...
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Sodium valproate (SV), an antiepileptic drug has several mechanism of action. It inhibits voltage sensitive Na+ channels and reduces intracellular Na accumulation. These actions are similar to that of both phenytoin and carbamazepine. We have investigated the direct cardiac action of SV and its effects on ouabain-induced arrhythmia in isolated guinea-pig atria. The guinea-pig atrium was dissect...
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In 1969, the Servier Laboratoires introduced trimetazidine, 1-(2, 3, 4-trimethoxybenzyl) piperazine dihydrochloride (Vastarel®) as a medicament for angina pectoris (1). This drug is assumed to reveal its remarkable action through decreasing cardiac work and lower ing the oxygen consumption of the heart (2), but other mechanisms of its action yet await ed clarification. Since trimetazidi...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1989
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1989.tb12026.x